Bread wheat is one of the fundamental sources of food supply in the world. Bread wheat has the biggest share in providing the human diet calories. Increasing in human population has led to a higher demand for wheat productivity in the world. Abiotic stresses, including micronutrient deficiencies, are among the most important limitation for wheat production. It is estimated that more than 50% of yield reduction is cased by direct impacts of such stresses. Although iron is required by plants in small amounts, it plays an essential role in the structure of chloroplasts and the growth and development of plants. Iron and zinc, as cofactors for some antioxidant enzymes, increase the activity of these enzymes and plays an important role in modulating free radicals and their destructive effects in membrane systems and consequently increase plant tolerance against drought stress. Iron deficiency stress in plants is associated with the creation of various types of reactive oxygen species (ROS), which in turn induces oxidative stress in the plant. To reduce the destructive effects of free oxygen radicals, plants develop various mechanisms, including the production of enzymatic and non-enzymatic antioxidant compounds. Antioxidant enzymes such as catalase, peroxidase, superoxide dismutase and polyphenol oxidase are activated under stress conditions and scavenge the ROS. An increase in the activity of different antioxidant enzymes as well as up-regulation of antioxidant encoding genes in response to the micronutrients deficiency have been reported in many studies.